Abnormal clot microstructure formed in blood containing HIT-like antibodies
نویسندگان
چکیده
منابع مشابه
Salivary microvesicles clot blood.
The capacity of saliva to clot blood has been documented in the scriptures (Luke 16:21), folklore, and in the medical literature of the 1920s when Hunter described the ability of saliva to clot blood and proposed it as a means to attenuate bleeding from gastric ulcers.1 In 1938, Glazko and Greenberg reported that saliva contains a cell-derived, protein-based thromboplastin,2 which was later ide...
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I N PREVIOUS REPORTS1-3 various methods, including radiotracer studies, revealed the capacity of plasmin to adsorb selectively to preformed venous and arterial clots. Components of the fibrinolysin system were labeled with iodine131 and their distribution studied following intravenous administration. The highest degree of adsorption to fibrin clots was exhibited by human plasminogen activated w...
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Antiplatelet factor 4 (PF4) antibodies have an important role in the most frequent drug-induced immune disorder, heparin-induced thrombocytopenia (HIT). In this issue of Blood, Sachais and coworkers propose a new feature that may explain why only some anti-PF4 antibodies are pathogenic.(1) In addition to epitope specificity-determining affinity and a high titer, the ability of antibodies to pro...
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ژورنال
عنوان ژورنال: Thrombosis Research
سال: 2020
ISSN: 0049-3848
DOI: 10.1016/j.thromres.2020.05.029